搜索
热搜: 活动 交友 discuz
banner03

中心PIPI

中心PI

首页 门户 研究队伍 中心PI

唐海宝教授

PostTime:2017-3-8 10:46 阅读人数:1157

唐海宝,教授,博士生导师,福建省“百人计划”专家。2009年12月获得美国佐治亚大学植物学博士学位。在比较基因组、群体遗传学等取得优异的成绩,是基因组序列装配注释、基因组比较分析、变异分析的专家。先后在Science,Nature Nature Genetics Nature Plant PNAS Genome Research等权威刊物发表文章60多篇。
主要研究方向:群体遗传学;多倍体作物基因组组成;作物基因组驯化和人工选择;计算生物学方法;分析平台的开发和应用。
电子邮箱:tanghaibao@gmail.com.
主要研究专长    
1. 发现并推测被子植物进化中发生的多次古代基因组复制(多倍化)事件并阐述单双子叶植物基因组结构和基因家族的进化过程。该项研究对于推测基因组间同源区段以及同源基因有非常重要的意义。    
2.在比较基因组学领域发明了新的算法和软件,其中MCSCAN,QUOTA-ALIGN已经成为很多基因组项目用于基因组比较的必备软件并被引用上百次。开发了高性能的生物信息学分析平台和数据库,比如植物基因组复制数据库(PGDD),以及COGE比较基因组分析平台。    
3. 参加了多项植物基因组装配及分析工作,包括木瓜,高粱,苜蓿,白菜,花菜,油菜,番茄,棉花,柳树,Amborella,莲花等14项重要基因组项目。尤其对于杂合度高或者多倍体的复杂基因组装配及分析处于领先水平。    
4. 定位和克隆禾本科作物驯化过程中的重要基因。通过基因组关联性分析和图位克隆的手段,发现高粱的花期基因和脱粒基因。发现并阐明了在多倍体物种里亚基因组的相互作用和染色体间协同进化方式。
专利     Paterson A, Tang, H. SORGHUM GRAIN SHATTERING GENE AND USES THEREOF IN ALTERING SEED DISPERSAL (高粱脱粒基因). WO Patent 2,013,006,861
代表论文(Google Scholar)    
66)Tang H. (2017). Disentangling a polyploid genome. Nature Plants doi:10.1038/s41477-017-0001-0 .
65)Zhang X, Chen X, Liang P, Tang H*. (2017) Cataloging plant genome structural variations.Current Issues in Molecular Biology. 27:181-94.
64)Tang H, Bomhoff MD, Briones E, Zhang L, Schnable J, Lyons E. (2015) SynFind: compiling syntenicregions across any set of genomes on demand. Genome Biol and Evol. 7(12):3286-3298.
63) Ming R#, Vanburen R#, Wai C#, Tang H#, et al. (2015) The pineapple genome and the evolution of CAM photosynthesis. Nature Genetics. 47(12):1435-1442.
62)Tang H, Lyons E, Town CD. (2015) Optical mapping in plant comparative genomics. Gigascience, 4:3.
61)Tang H, Zhang X, Miao C, Zhang J, Ming R, Schnable J, Schnable P, Lyons E, Lu J. (2015)ALLMAPS:robust scaffold ordering based on multiple maps. Genome Biol. 16(1):3.
60)Jiao Y#, Li J#, Tang H#, Paterson AH (2014). Integrated Syntenic and Phylogenomic Analyses Reveal an Ancient Genome Duplication in Monocots. Plant Cell. pii: tpc.114.127597.
59)Tang H, Lyons E, and Schnable JC. (2014) Early History of the Angiosperms. Genomes of Herbaceous Land Plants, Elsevier.
58)Tang H, Cuevas HE, Das S, Sezen UU, Zhou C, et al. (2013) Seed shattering in a wild sorghum is conferred by a locus unrelated to domestication. Proc Natl Acad Sci U S A, 110, 15824-15829.
57)Yang X, Hu R, Yin H, Jenkins J, Shu S, Tang H, … et al. (2017). The Kalanchoe genome provides insights into convergent evolution and building blocks of crassulacean acid metabolism. Nat Commun8: 1899. 
56)Harkess A,Tang H, et al. (2017). The asparagus genome sheds light on the origin and evolutionof a young Y chromosome. Nat Commun 8: 1279.
55)Chen F, Liu X, Yu C, Chen Y, Tang H, Zhang L. (2017). Water lilies as emerging models for Darwin’sabominable mystery. Horticulture Research 4: 17051.
54)Bao J, … Tang H, … et al. (2017). PacBio Sequencing Reveals Transposable Element as a Key Contributor to Genomic Plasticity and Virulence Variation in Magnaporthe oryzae. Mol Plant doi:10.1016/j.molp.2017.08.008. 14. Xu S, … Tang H, ... et al. (2017). Wild tobacco genomes reveal the evolution of nicotine biosynthesis.Proc Natl Acad Sci U S A 114:61338
53)Qin G, Xu C, Ming R, Tang H, Guyot R, et al. (2017). The pomegranate (Punica granatum L.) genomeand the genomics of punicalagin biosynthesis. Plant J doi:10.1111j.13625.
52)Lan T, Renner T, … Tang H, … et al. (2017). Long-read sequencing uncovers the adaptive topography of a carnivorous plant genome. Proc Natl Acad Sci U S A 114:E4435-E41
51)Golicz AA, ..., Tang H, Teakle GR, Town CD, Batley J, Edwards D. (2016). The pangenome of an agronomically important crop plant Brassica oleracea. Nat Commun 7: 13390.
50)Han J, Masonbrink RE, Shan W, Song F, Zhang J, Yu W, Wang K, Wu Y, Tang H, Wendel JF, Wang K.(2016) Rapid proliferation and nucleolar organizer targeting centromeric retrotransposons in cotton.Plant J. doi: 10.1111j.13309.
49)Lee H, Golicz AA, Bayer P, Jiao Y, Tang H, Paterson AH, Sablok G, Krishnaraj RR, Chan CK, BatleyJ et al. (2016) The genome of a southern hemisphere seagrass species (Zostera muelleri). Plant Physioldoi:10.1104.16.00868.
48)Cuevas HE, Zhou C, Tang H, Khadke PP, Das S, Lin YR, Ge Z, Clemente T, Upadhyaya HD, Hash CTet al. (2016) The Evolution of Photoperiod-Insensitive Flowering in Sorghum, A Genomic Model for Panicoid Grasses. Mol Biol Evol doi:10.1093/molbev/msw120.
47)Zhong Z, … Tang H, ... Wang Z. (2016) Directional Selection from Host Plants Is a Major Force Driving Host Specificity in Magnaporthe Species. Sci Rep 6: 25591.
46) McKain MR, Tang H, McNeal JR, Ayyampalayam S, Davis JI, dePamphilis CW, Givnish TJ, Pires JC,Stevenson DW, Leebens-Mack JH. (2016) A Phylogenomic Assessment of Ancient Polyploidy andGenome Evolution across the Poales. Genome Biol Evol 8: 1150-1164.
45)Wang X, Guo H, Wang J, Lei T, Liu T, Wang Z, Li Y, Lee TH, Li J, Tang H et al. (2016)Comparative genomic deconvolution of the cotton genome revealed a decaploid ancestor and widespread chromosomal fractionation. New Phytol 209: 1252-1263.
44)Sankoff D, Zheng C,Lyons E,and Tang H (2016).The Trees in the Peaks.Algorithms for Computational Biology:Third International Conference,AlCoB 2016 Proceedings (pp.3-43).Springer International Publishing.
42)Vanburen R, Bryant D, Edgar PP, Tang H, et al. (2015) Insights into desiccation tolerance and genome compaction: single-molecule sequencing of the grass Oropetium thomaeum. Nature, doi:10.1038/nature15714
41)Hofberger JA, Zhou B, Tang H, Jones JD, Schranz ME. (2014) A novel approach for multidomain and multi-gene family identification provides insights into evolutionary dynamics of disease resistance genes in core eudicot plants. BMC Genomics 2014, 15:966.
40)Chalhoub, B, ... Tang, H, … Wincker, P. (2014) Early allopolyploid evolution in the post-Neolithic Brassica napus oilseed genome. Science 2014, 345(6199):950-953.
39)Li J, Tang H, Bowers JE, Ming R, Paterson AH. (2014) Insights into the Common Ancestor of Eudicots. Genomes of Herbaceous Land Plants, Elsevier  
38)Paterson, AH, …, Tang, H, …, Schmutz, J (2012) Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres. Nature, doi:10.1038/nature11798    
37)Lee, TH, Tang, H, Wang, X, Paterson, AH (2012) PGDD: a database of gene and genome duplication in plants. Nucleic Acids Research, 1–7, doi:10.1093/nar/gks1104    
36) Tang, H, Lyons, E (2012) The Evolution of Genome Structure. Int J Evol, 1:1 (Editorial)    
35)Lu, J, Peatman, E, Tang, H, Lewis, J, Liu, Z (2012) Profiling of gene duplication patterns of sequenced teleost genomes: evidence for rapid lineage-specific genome expansionmediated by recent tandem duplications. BMC Genomics, 13: 246.    
34)Sato, S, …, Tang, H, …, Klein Lankhorst, RM (2012) The tomato genome sequence provides insights into fleshy fruit evolution.Nature, 485: 635-641.    
33)Tang, H, Woodhouse, MR, Cheng, F, Schnable, JC, Pedersen, BS, et al. (2012) Altered patterns of fractionation and exon deletions in Brassica rapa support a two-step model of paleohexaploidy. Genetics, 190:1563-1574 (First Author).    
32)Wang, Y*, Tang, H*, Debarry, JD, Tan, X, Li, J, et al. (2012) MCScanX: a toolkit for detection and evolutionary analysis of gene synteny and collinearity. Nucleic Acids Research, 40: e49 (co-First Author).    
31)Woodhouse, MR, Tang, H, Freeling, M. (2011) Different gene families in Arabidopsis thaliana transposed in different epochs and at different frequencies throughout the rosids. Plant cell, 23: 4241-4253.    
30)Wang, Y, Wang, X, Tang, H, Tan, X, Ficklin, SP, et al. (2011) Modes of Gene Duplication Contribute Differently to genetic novelty and redundancy, but show parallels across divergent angiosperms. PLoS One, 6: e28150.    
29)Young, ND, …, Tang, H, …, Roe, B (2011) The medicago genome provides insight into the evolution of rhizobial symbioses. Nature, 480: 520-524.    
28)Wang, X, …, Tang, H, …, Zhang, Z (2011) The genome of the mesopolyploid crop species Brassica rapa. Nature Genetics, 43: 1035-1039.    
27)Zuccolo, A, …, Tang, H, …, Leebens-Mack, J (2011) A physical map for the Amborella trichopoda genome sheds light on the evolution of angiosperm genome structure. Genome Biology, 12: R48.    
26)Ratnaparkhe, MB, …, Tang, H, …, Paterson, AH (2011) Comparative analysis of peanut NBSLRR gene clusters suggests evolutionary innovation among duplicated domains and erosion of gene microsynteny. New Phytologist, 192: 164-178.    
25)Lin, L, Tang, H, Compton, RO, Lemke, C, Rainville, LK, et al. (2011) Comparative analysis of Gossypium and Vitis genomes indicates genome duplication specific to the Gossypium lineage. Genomics, 97: 313-320.    
24)Pedersen, BS, Tang, H, Freeling, M (2011) Gobe: an interactive, web-based tool for comparative genomic visualization.Bioinformatics, 27(7):1015-6.    
23)Wang, X, Tang, H, Paterson, AH (2011) Seventy million years of concerted evolution of a homoeologous chromosome pair, in parallel, in major Poaceae lineages. Plant Cell, 23(1):27-37.  
22)Tang, H, Lyons E, Pedersen B, Schnable JC, Paterson AH, Freeling M (2011) Screening synteny blocks in pairwise genome comparisons through integer programming. BMC Bioinformatics, 12: 102 (First Author).    
21)Tang, H, Sezen, U, and Paterson, AH (2010) Domestication and plant genomes. Current Opinion in Plant Biology, 13(2):160-6(First Author).    
20)Tang, H, Bowers, JE, Wang, X, and Paterson, AH (2010) Angiosperm genome comparisons reveal early polyploidy in the monocot lineage. PNAS, 107(1): 472-7 (First Author).    
19)Lin, L, …, Tang, H, …, Paterson, AH (2010) A draft physical map of a D-genome cotton species (Gossypium raimondii). BMC Genomics, 11(1):395.    
18)Paterson, AH, Freeling, M, Tang, H, Wang, X (2010) Insights from the comparison of plant genome sequences. Annual Review of Plant Biology, 61: 349-72.    
17)Wang, J, …, Tang, H, …, Ming R (2010) Microcollinearity between autopolyploid sugarcane and diploid sorghum genomes. BMC Genomics, 11(1): 261.    
16)Li, G, Ma, Q, Tang, H, Paterson, AH and Xu, Y (2009) QUBIC: a qualitative biclustering algorithm for analyses of gene expression data. Nucleic Acid Research, 37: e101.    
15)Charles, M, Tang, H, Belcram H, Paterson A, Gornicki P, et al. (2009) Sixty million years in evolution of soft grain trait in grasses: emergence of the softness locus in the common ancestor of Pooideae and Ehrhartoideae, after their divergence from Panicoideae. Molecular Biology and Evolution, 26: 1651-1661.    
14)Wang, X, Tang, H, Bowers, JE, Paterson, AH (2009) Comparative inference of illegitimate recombination between rice and sorghum duplicated genes produced by polyploidization. Genome Research, 19: 1026-1032.    
13)Paterson, AH, Bowers, JE, Feltus, FA, Tang, H, Lin, L, Wang, X (2009) Comparative genomics of the grasses: Promising a bountiful harvest. Plant Physiology, 149, 125-131.    
12)Paterson, AH, …, Tang, H, …, Rokhsar, DS (2009) The Sorghum bicolor genome and the diversification of grasses. Nature, 457, 551-556.    
11)Wang, X, Gowik, U, Tang, H, Bowers, JE, Westhoff, P, Paterson, AH (2009) Comparative genomic analysis of C4 photosynthetic pathway evolution in grasses. Genome Biology, 10: R68.    10)Kim, C, Tang, H and Paterson, AH (2009) Duplication and Divergence of Grass Genomes: Integrating the Chloridoids. Tropical Plant Biology, 2, 51-62.    
9)Che, D, Tang, H and Song, Y (2009) Haplotype inference using a genetic algorithm. Proceedings of IEEE Bioinformatics and Computational Biology, 31-37.     
8)Lyons, E, …, Tang, H, …, Freeling, M (2008) Finding and Comparing Syntenic Regions among Arabidopsis and the Outgroups Papaya, Poplar, and Grape: CoGe with Rosids. Plant Physiology, 148, 1772-81.     
7)Jang, CS, Kamps, TL, Tang, H, Bowers, JE, Lemke, C, Paterson, AH (2008) Evolutionary fate of rhizome-specific genes in a non-rhizomatous Sorghum genotype. Heredity 102: 266-273.     
6)Tang H, Bowers JE, Wang X, Ming R, Alam M, Paterson AH (2008) Synteny and Collinearity in Plant Genomes, Science, 320, 486-488 (First Author).     
5)Tang H, Wang X, Bowers JE, Ming R, Alam M, Paterson AH (2008) Unraveling ancient hexaploidy through multiply-aligned angiosperm gene maps, Genome Research, 18, 1944-1954 (First Author).     
4)Ming, R, ..., Tang, H, …, Alam M (2008) The draft genome of the transgenic tropical fruit tree papaya (Carica papaya Linnaeus),Nature, 452, 991-996.     
3)Wang, X, Tang, H, Bowers, JE, Feltus, FA, Paterson, AH (2007) Extensive concerted evolution of rice paralogs and the road to regaining independence, Genetics, 177, 1753-1763.     
2)Liu, Q, Ge, S, Tang, H, Zhang, X, Zhu, G, Lu, BR (2006) Phylogenetic relationships in Elymus (Poaceae: Triticeae) based on the nuclear ribosomal internal transcribed spacer and chloroplast trnL-F sequences, New Phytologist, 170, 411-420.     
1)Bowers, JE, …, Tang, H, Wing, RA, Paterson, AH. (2005) Comparative physical mapping links conservation of microsynteny to chromosome structure and recombination in grasses, PNAS, 102, 13206-13211

唐海宝老师课题组成员

上一篇:王凯教授

下一篇:秦源教授

扫一扫微信公众平

weixin
返回顶部